Olink® Proteomics

Cutting-Edge Multiplex Immunoassay for Biomarker Discovery

The Centre for Diagnostics offers advanced Olink services to researchers, hospitals and companies, enabling high-throughput proteomic analysis of research samples. The Olink technology represents a breakthrough in proteomics, providing sensitive, precise, and scalable protein biomarker quantification. At its core is the Proximity Extension Assay (PEA), a unique immunoassay that combines antibody-based detection with DNA barcoding, allowing for the simultaneous detection and relative quantification of 5 to more than 5400 protein biomarkers covering a wide range of biological pathways and processes. In omics research, bioinformatics is essential. At the Centre for Diagnostics, we are proud to collaborate with Biogenity, a contract research organization specializing in omics research and discovery, to bring you unparalleled data analysis services tailored for our Olink pipeline.

Olink® Services

Why Choose Olink® for your Research Projects?

Olink's rapid and comprehensive protein analysis accelerates biomarker discovery and clinical development. Its proven efficiency has made it the platform of choice for leading research institutions and pharmaceutical companies worldwide. It offers high specificity through dual PEA antibody detection, high sensitivity through PCR amplification, a dynamic range that is physiologically relevant and can span over 10 logs, and the ability to work with minimal precious sample volume (1 µl for one Olink Target Panel and less than 10 µl for Olink Explore). In addition, Olink technology has proven to be fully scalable with reproducible data across the different Olink platforms and for studies of any sample size, including large cohort studies.
  • High specificity: Dual antibody recognition and barcoding with PEA
  • High throughput or small scale: Analyze thousands of samples with a turnaround time of just two weeks. Depending on the panel, screenings range from 5 to over 5400 biomarkers.
  • High sensitivity and broad dynamic range: High sensitivity provided through PCR amplification; physiologically relevant dynamic range can span over 10 logs.
  • Low sample volume: Detect low-abundance proteins using minimal sample volumes 1 µl for Olink ® Target, 1-2 µl for Olink ® Explore, and 2 µl for Olink ® HT panels.
  • Adaptable to different sample types: Validated with plasma and serum with other matrices tested successfully.
  • Reproducibility and robustness: Olink’s highly standardized assay ensures consistent results across different experiments and labs.
  • High-quality, actionable data: Thoroughly validated and normalized data that can guide clinical decisions, treatment plans, and future research.

Our Olink® Services

When you're seeking to collaborate on cutting-edge diagnostic research or need advanced protein biomarker data, our Olink proteomics service is the ideal solution. As your local DTU partner in Lyngby, we are here to support your project from start to finish, ensuring high-quality and reliable results at every step. As a Certified Olink Service Provider, we offer comprehensive proteomic analysis tailored to the needs of academic researchers, biotech companies, pharmaceutical developers, and clinicians. We require a minimal sample volume of 40-50 µl for robotic transfer, but return the remaining sample material after analysis.

To enhance our data analysis capabilities, we have established a formal partnership with Biogenity, a CRO specializing in omics research and discovery. The Centre for Diagnostics at DTU, in collaboration with Biogenity, is committed to going beyond basic analysis to provide detailed and clear data interpretation for our customers and collaborators. Our service includes pre-consultation, sample analysis, and seamless data transfer for bioinformatic analysis, handled directly by Biogenity, so you can focus entirely on your research. All you need to provide are the samples – we manage the rest.

With a wide range of Olink® panels designed for diverse applications, we are here to help you choose the right one for your project. For more information on which panel to choose, please reach out to CfD’s Olink Insight Expert, Ilaria Mainero Rocca. For collaboration opportunities please reach out to our Head of Centre, Helene Larsen.

 

Ilaria Mainero Rocca

Ilaria Mainero Rocca Department of Health Technology

Helene Larsen

Helene Larsen Head of Center - Center for Diagnostics Department of Health Technology Mobile: +45 42440166